FRITS FOR CHROMATOGRAPHY
HIGH PERFORMANCE LIQUID CHROMATOGRAPHY (HPLC):
It is a form of column chromatography that pumps a sample mixture or analyte in a solvent (known as the mobile
phase) at high pressure through a column with chromatographic packing material (stationary phase). The sample is
carried by a moving carrier gas stream of helium or nitrogen.
Depending on the chemical structure of the sample, the molecules are slowed down while passing through the
stationary phase. The specific interactions between the molecules of a sample and the packing material define their
time. Hence, different constituents of a sample are eluted at different times. Thereby, the separation of the sample
ingredients is achieved.
WHAT ARE CHROMATOGRAPHY FRITS?
Chromatography Frits are Inert physical filtration devices, typically installed before pre-columns, that provide a coarse
filtration of the HPLC eluent and prevent contaminant particles from reaching the HPLC system.
Frits are used to eliminate the traditional inline filters and reduce the number of connections in the process
Use of G BOPP Frits in HPLC :
We are the sole business associate for G BOPP-Switzerland since last decade to supply
Chromatography-Frits in INDIA.
We can supply the same from Pilot scale to Industrial scale ( i.e. from 50 mm to 1200 mm & above)
MOC available are SS-316L / SS-904 L / Hastelloy C-22 grade
G BOPP Frits are basically Multi-Layer Sintered mesh with exact micron ratings of 2 / 5 /10 / 20 micron & above.
APPLICATION OF HPLC FRITS:
Manufacturing: HPLC frits have many applications in both laboratory and clinical science. It is a common technique
used in pharmaceutical development, as it is a dependable way to obtain and ensure product purity. While HPLC can
produce extremely high quality (pure) products, it is not always the primary method used in the production of bulk
drug materials.
Research: Similar assays can be performed for research purposes, detecting concentrations of potential clinical
candidates like antifungal and asthma drugs. This technique is obviously useful in observing multiple species in
collected samples, as well, but requires the use of standard solutions.
Medical: Medical use of HPLC can include drug analysis, but falls more closely under the category of nutrient
analysis. While urine is the most common medium for analyzing drug concentrations, blood serum is the sample
collected for most medical analyses with HPLC.
Some other applications:
- 1. Water purification
- 2. Detection of impurities in pharmaceutical industries
- 3. Pre-concentration of trace components
- 4. Ligand-exchange chromatography
- 5. Ion-exchange chromatography of proteins
- 6. High-pH anion-exchange chromatography of carbohydrates and oligosaccharides
G.Bopp® Chromatography Frits
